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. 2023 Feb 8;22(3):e13768. doi: 10.1111/acel.13768

FIGURE 2.

FIGURE 2

LV‐remodeling and LV dysfunction in DNA repair‐deficient mutants at a specific time point (study II). (a) Effect of Xpg and Ercc1 deficiency on LV mass and geometry and (b), hemodynamic parameters in 16‐week‐old Xpg −/− and αMHC‐Xpg c/− , 8‐week‐old Ercc1 −/− , 16‐week‐old Ercc1 Δ/− and αMHC‐Ercc1 c/− mice and corresponding control (n = 7–16 animals/group). LV weight, left ventricular weight; BW, body weight; LVEDD, LV end‐diastolic lumen diameter; LVdP/dtmax, maximum rate of rise of LV pressure; LVdP/dtmin, maximum rate of fall of LV pressure; tau, relaxation time constant; LVEDP, LV end‐diastolic pressure. Data are presented as mean ± SEM. *p < 0.05 vs. corresponding control by two‐way ANOVA followed by SNK post hoc testing.