Skip to main content
. 2023 Mar 15;133(6):e164919. doi: 10.1172/JCI164919

Figure 2. Effect of glial pathology on the vasculature and myelination in thalamus and frontal cortex of patients with FTLD-GRN.

Figure 2

(A) Immunostains for CD34 in hTH and hFCX in control and FTLD-GRN cases. (B) Confocal images for CD34, IBA1, and GFAP showing IBA1+ microglia engulfing CD34+ debris in FTLD-GRN (arrowheads). (C) Immunohistochemical stains for MBP in hTH and hFCX in control and FTLD-GRN cases. (D) Confocal images showing IBA1+ microglia and GFAP+ astrocytes engulfing MBP+ myelin debris (arrowheads) in FTLD-GRN. L1/2 indicates the border between layers 1 and 2 of the frontal cortex. Scale bars: 20 μm (A and C, bottom; B; and D, left); 40 μm (D, right); 300 μm (A and C, top).