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. 2023 Mar 15;133(6):e165245. doi: 10.1172/JCI165245

Figure 2. Paired full-genome sequencing and integration site analysis of 5′-L–defective proviruses causing NSV.

Figure 2

(A) Mapped sequences of proviruses contributing to plasma HIV-1 RNA in each participant. Proviruses of interest are color-coded throughout the figure. Light-shaded areas indicate small 5′-L deletions. Stars indicate point mutations affecting the MSD site. (B) Percentage contributions to NSV of defective proviruses of interest. (C) 5′-L defects aligned to the HXB2 reference. DIS, dimerization initiation signal; PSI, packaging signal; AUG, Gag start codon. Dashes indicate length polymorphisms. Gray lines highlight GAG repeats at deletion junctions causing misplaced jumping of reverse transcriptase (dashed gray arrows). (D) Chromosomal and gene locations of proviruses causing viremia. Sets of arrows indicate direction of proviral and host gene transcription. Schematic gene tracks are shown in black, with vertical bars representing exons.