Figure 2.
(A–C) Effect of oxytocin (OT) (vehicle, 0.1, 0.25, 0.5, 1.0, and 2.0 mg/kg) on response rate for food self-administration compared with methylphenidate (MP) self-administration at MP doses of (A) 0.01 mg/kg/infusion, (B) 0.03 mg/kg/infusion, and (C) 0.1mg/kg/infusion. (D-F) Effect of oxytocin (OT) (vehicle, 0.1, 0.25, 0.5, 1.0, and 2.0 mg/kg) on percentage of baseline response rate for food self-administration compared with methylphenidate (MP) self-administration at MP doses of (D) 0.01 mg/kg/infusion, (E) 0.03 mg/kg/infusion, and (F) 0.1mg/kg/infusion. For food, there was a significant reduction from baseline only at the 2 mg/kg dose of OT (*P < 0.05 ); ****P < 0.0001: significant reduction from baseline for MP, see Figure 1. B = baseline.