Table 1.

Pharmacokinetic parameters of PSL after intravenous administration of free PSL, Cys-PSL, and CRV-PSL to mice (1 mg kg⁻¹ equivalent dose of PSL per mouse)

Pharmacokinetic parameters	Free PSL	Cys-PSL	CRV-PSL
T1/2 (h)	3.78 ± 0.50	4.47 ± 0.22	6.13 ± 2.59
AUC0-t	41,279.66 ± 5,527.07	82,414.35 ± 3,511.63∗	82,880.57 ± 3,611.63∗

Values are expressed as mean ± SD (n = 3), ∗p < 0.001 relative to free PSL. T_1/2, half-life; AUC_0-t, area under the concentration-time curve.