Figure 2.

Anti-AAV antibody seroprevalence ranges for different AAV serotypes and across geographical regions using the hemophilia A and B population as an example

The published anti-AAV antibody seroprevalence rates vary widely according to a variety of factors, including (A) different AAV serotypes,^{18,34,35,36,37,38,39,40,41,42} and (B) across geographical regions (using AAV6 data from three separate reports as an example).^34,36,42 Other factors that may influence seroprevalence rates include assay type, donor health and age, and the use of some medications, such as immunosuppressants. ∗As these studies were performed in different regions/countries using different assay types, the seroprevalence rates cannot be directly compared. AAV, adeno-associated virus; TAb, total antibody; TI, transduction inhibition.