Table 2.

Analysis of methylation variance

CpG	Gene	Group	Location	logFC	Average M	Average beta	p-value	Adjusted p
cg16826718	HRK	3′UTR	North shore	−1.798	0.869	0.646	2.32E-08	0.008
cg06895197	PHF12	TSS200	North shore	−1.367	0.665	0.613	2.34E-08	0.008
cg09672912	–	–	–	−3.484	1.714	0.766	1.02E-07	0.022
cg11521799	SNRPB	TSS200	South shore	−1.591	0.928	0.655	1.51E-07	0.025
cg14459930	JKAMP/L3HYPDH	5′UTR/1stExon/TSS1500/body	South shore	−1.907	0.892	0.650	1.92E-07	0.025
cg27507339	SLCO5A1	5′UTR/TSS1500	Island	−1.627	0.969	0.662	4.30E-07	0.036
cg16877339	–	–	–	−1.504	0.769	0.630	4.38E-07	0.036
cg07866632	CCDC101	5′UTR	–	−1.071	0.605	0.603	5.13E-07	0.036
cg14451561	AMACR/C1QTNF3	TSS1500/body	South shore	−1.442	0.891	0.650	5.35E-07	0.036
cg03558326	C14orf167/DHRS4	Body/1stExon	Island	−1.300	0.823	0.639	5.48E-07	0.036
cg19507893	–	–	North shore	−1.029	0.615	0.605	6.49E-07	0.036
cg00222056	TMEM14A	TSS1500	North shore	−1.398	0.747	0.627	6.55E-07	0.036
cg13536076	ERICH6-AS1	Body	South shelf	−1.386	0.935	0.657	8.07E-07	0.041
cg21223075	BHLHE40	TSS1500	Island	1.996	0.630	0.608	8.99E-07	0.042
cg22746566	C2CD2	5′UTR/body	–	−1.063	0.546	0.593	9.93E-07	0.044
cg27587195	MCC	5′UTR/1stExon	Island	−1.705	0.892	0.650	1.18E-06	0.048
cg18109941	PLXDC2	1stExon/5′UTR	Island	−1.599	1.021	0.670	1.24E-06	0.048

The table displays results from the single CpG analysis of methylation variance in the complete dataset. Only the 17 CpGs with statistically significant differences in methylation variance after correcting for multiple testing are shown. logFC: log-fold change in methylation variance. TSS1500/TSS200: promoter regions 1500/200 base pairs upstream from the transcription start site. Adjusted p: FDR corrected p values. Gene/location mappings are from the Illumina manifest (Infinium MethylationEPIC v1.0 B5) which in turn is based on the USCS database.³²