Table 3.
Univariate and multivariate logistic regression of variables predicting complete response to nCRT (neoadjuvant chemoradiation).
| VARIABLE | pCR, n (%) | UNIVARIATE | MULTIVARIATE |
|---|---|---|---|
| GENDER Male Female |
113 (26.0) 65 (23.5) |
p = 0.45 1.15 (0.81–1.63) 1.00 |
|
| AGE, years <65 ≥65 |
81 (22.6) 97 (27.4) |
p = 0.14 1.00 1.29 (0.92–1.81) |
|
| cT 1–2 3 4 |
14 (31.1) 122 (24.9) 33 (21.4) |
p = 0.39 1.00 0.74 (0.38–1.43) 0.60 (0.29–1.26) |
|
| cN negative positive |
30 (23.3) 143 (24.9) |
p = 0.69 1.00 1.10 (0.70–1.72) |
|
| EXTRAMESORECTAL NODES no yes |
120 (24.7) 39 (25.2) |
p = 0.91 1.00 1.03 (0.68–1.56) |
|
| CONCOMITANT CT single agent double agent |
131 (25.5) 45 (23.4) |
p = 0.58 1.00 0.89 (0.61–1.32) |
|
| RT, Gy <55 ≥55 |
57 (21.7) 121 (26.9) |
p = 0.12 1.00 1.33 (0.93–1.91) |
|
| SURGICAL INTERVAL, weeks <12 ≥12 |
99 (23.2) 79 (27.7) |
p = 0.17 1.00 1.27 (0.90–1.79) |
|
| NLR <=1.2 >1.2 |
14 (48.3) 164 (24.0) |
p = 0.005 1.00 0.34 (0.16–0.72) |
p = 0.05 1.00 0.46 (0.21–1.00) |
| PLR <=200 >200 |
149 (27.6) 29 (16.9) |
p = 0.005 1.00 0.53 (0.34–0.83) |
--- |
| SII <=500 >500 |
83 (32.0) 95 (21.0) |
p = 0.001 1.00 0.56 (0.40–0.79) |
p = 0.009 1.00 0.62 (0.43–0.89) |
| MLR <=0.38 >0.38 |
158 (26.9) 20 (16.0) |
p = 0.012 1.00 0.52 (0.31–0.86) |
--- |
| HEI 0–1-2 3 |
158 (25.6) 20 (21.3) |
p = 0.37 1.00 0.79 (0.46–1.33) |
CT: chemotherapy; Gy: Gray; HEI: hemo-eosinophils inflammation index; MLR: monocyte-to-lymphocyte ratio; NLR: neutrophil-to-lymphocyte ratio; PLR: platelet-to-lymphocyte ratio; RT: radiotherapy; SII: systemic index of inflammation. In bold the statistically significant values.