Table 4.
Univariate and multivariate Cox regression analysis of variables predicting disease-free survival (DFS).
| VARIABLE | Events, n (%) | UNIVARIATE | MULTIVARIATE |
|---|---|---|---|
| GENDER Male Female |
207 (42.2) 111 (35.5) |
p = 0.16 1.18 (0.94–1.48) 1.00 |
|
| AGE, years <65 ≥65 |
131 (32.5) 187 (46.6) |
p < 0.0001 1.00 1.68 (1.34–2.10) |
p = 0.002 1.00 1.49 (1.16–1.94) |
| cT 1–2 3 4 |
27 (46.6) 214 (38.7) 72 (42.9) |
p = 0.16 1.00 0.74 (0.50–1.10) 0.90 (0.58–1.40) |
|
| cN negative positive |
53 (34.4) 264 (41.2) |
p = 0.034 1.00 1.38 (1.02–1.86) |
--- |
| EXTRAMESORECTAL NODES no yes |
198 (34.8) 80 (48.5) |
p < 0.0001 1.00 1.59 (1.23–2.07) |
p = 0.02 1.00 1.42 (1.07–1.88) |
| CONCOMITANT CT single agent double agent |
239 (40.4) 69 (34.3) |
p = 0.15 1.00 0.82 (0.63–1.07) |
|
| RT, Gy <55 ≥55 |
116 (36.6) 202 (41.5) |
p = 0.002 1.00 1.44 (1.14–1.82) |
p = 0.008 1.00 1.46 (1.10–1.94) |
| SURGICAL INTERVAL, weeks <12 ≥12 |
176 (39.6) 120 (37.6) |
p = 0.030 1.00 1.30 (1.03–1.66) |
--- |
| NLR <=2.5 >2.5 |
158 (38.6) 160 (40.5) |
p = 0.69 1.00 1.05 (0.84–1.30) |
|
| PLR <=100 >100 |
60 (35.9) 258 (40.5) |
p = 0.52 1.00 1.10 (0.83–1.45) |
|
| SII <=500 >500 |
118 (40.0) 200 (39.3) |
p = 0.89 1.00 1.02 (0.81–1.27) |
|
| MLR <=0.18 >0.18 |
52 (29.1) 266 (42.6) |
p = 0.01 1.00 1.46 (1.08–1.97) |
p = 0.03 1.00 1.43 (1.02–1.99) |
| HEI 0–1-2 3 |
267 (38.3) 51 (48.1) |
p = 0.009 1.00 1.49 (1.11–2.01) |
p = 0.05 1.00 1.35 (1.00–1.87) |
CT: chemotherapy; Gy: Gray; HEI: hemo-eosinophils inflammation index; MLR: monocyte-to-lymphocyte ratio; NLR: neutrophil-to-lymphocyte ratio; PLR: platelet-to-lymphocyte ratio; RT: radiotherapy; SII: systemic index of inflammation. In bold the statistically significant values.