Table 5.
Univariate and multivariate Cox regression analysis of variables predicting overall survival (OS).
| VARIABLE | Deaths, n (%) | UNIVARIATE | MULTIVARIATE |
|---|---|---|---|
| GENDER Male Female |
113 (23.0) 53 (16.9) |
p = 0.05 1.38 (0.99–1.91) 1.00 |
--- |
| AGE, years <65 ≥65 |
62 (15.4) 104 (25.9) |
p < 0.0001 1.00 2.09 (1.52–2.86) |
p < 0.0001 1.00 2.06 (1.50–2.83) |
| cT 1–2 3 4 |
12 (20.7) 112 (20.3) 38 (22.6) |
p = 0.54 1.00 0.83 (0.46–1.51) 1.01 (0.52–1.93) |
|
| cN negative positive |
30 (19.5) 135 (21.1) |
p = 0.24 1.00 1.27 (0.85–1.89) |
|
| EXTRAMESORECTAL NODES no yes |
97 (17.0) 29 (17.6) |
p = 0.20 1.00 1.32 (0.87–2.00) |
|
| CONCOMITANT CT single agent double agent |
120 (20.3) 40 (19.9) |
p = 0.62 1.00 0.91 (0.64–1.31) |
|
| RT, Gy <55 ≥55 |
91 (28.7) 75 (15.4) |
p = 0.04 1.00 0.72 (0.53–0.98) |
p = 0.04 1.00 0.73 (0.53–0.99) |
| SURGICAL INTERVAL, weeks <12 ≥12 |
109 (24.5) 44 (13.8) |
p = 0.66 1.00 0.92 (0.64–1.32) |
|
| NLR <=2.5 >2.5 |
70 (17.1) 96 (24.3) |
p = 0.05 1.00 1.36 (1.00–1.85) |
--- |
| PLR <=100 >100 |
24 (14.4) 142 (22.3) |
p = 0.10 1.00 1.44 (0.94–2.23) |
|
| SII <=500 >500 |
55 (18.6) 111 (21.8) |
p = 0.26 1.00 1.21 (0.87–1.67) |
|
| MLR <=0.35 >0.35 |
108 (17.6) 58 (30.4) |
p = 0.005 1.00 1.58 (1.15–2.18) |
p = 0.028 1.00 1.44 (1.04–1.98) |
| HEI 0–1-2 3 |
139 (19.9) 27 (25.5) |
p = 0.07 1.00 1.48 (0.98–2.23) |
p = 0.045 1.00 1.53 (1.01–2.32) |
CT: chemotherapy; Gy: Gray; HEI: hemo-eosinophils inflammation index; MLR: monocyte-to-lymphocyte ratio; NLR: neutrophil-to-lymphocyte ratio; PLR: platelet-to-lymphocyte ratio; RT: radiotherapy; SII: systemic index of inflammation. In bold the statistically significant values.