Table 2.
Association of time-varying urinary biomarkers with eGFR
| Biomarker | Mean Change (95% CI) | P-value |
|---|---|---|
| Creatinine (mg/dl) | −0.056 (−0.076, −0.036) | <0.0001a |
| Osmolality (mmol/kg) | −0.005 (−0.009, −0.001) | 0.0147a |
| Lactate (μM)/Ucrea | −0.270 (−0.692, 0.152) | 0.2091 |
| Lactate (μM)/Uosm | −8.364 (−17.507, 0.780) | 0.0729 |
| Lactate/Pyruvate | −0.407 (−0.794, −0.021) | 0.0388a |
| Succinate (μM)/Ucrea | 0.384 (−0.234, 1.003) | 0.2223 |
| Succinate (μM)/Uosm | −3.553 (−13.278, 6.172) | 0.4729 |
| Pyruvate (μM)/Ucrea | 1.870 (−0.242, 3.982) | 0.0825 |
| Pyruvate (μM)/Uosm | 0.805 (−30.386, 31.996) | 0.9595 |
| Total Protein (mg/dl)/Ucrea | −0.140 (−2.710, 2.431) | 0.9150 |
| Total Protein (mg/dl)/Uosm | −54.083 (−98.638, −9.528) | 0.0175a |
| PKM2 (ng/ml)/Ucrea | 1.881 (−0.568, 4.330) | 0.1318 |
| PKM2 (ng/ml)/Uosm | −10.697 (−41.326, 19.933) | 0.4927 |
| LDHA (ng/ml)/Ucrea | 0.185 (−8.768, 9.138) | 0.9676 |
| LDHA (ng/ml)/Uosm | −84.184 (−171.014, 2.645) | 0.0574 |
| PDK1 (pg/ml)/Ucrea | 0.042 (−0.061, 0.145) | 0.4231 |
| PDK1 (pg/ml)/Uosm | −0.196 (−2.123, 1.731) | 0.8415 |
CI, confidence interval; eGFR, estimated glomerular filtration rate; LDHA, lactate dehydrogenase-A; PDK1, pyruvate dehydrogenase kinase 1; PKM2, pyruvate kinase M2; Ucrea, urinary creatinine concentration; Uosm, urinary osmolality.
a
Significant P values.