Urine markers of kidney injury and cytokines. Box and whisker plots of markers of kidney and tubular injury in AKI-ICI vs. AKI-other groups: (a) NGAL, (b) KIM-1, (c) IL-2, (d) IL-4, (e) IL-6, (f) IL-8, (g) IL-9, (h) IL-10, (i) TNF-α, (j) INF-γ levels in the urine. The boxes extend from the 25th percentile to the 75th percentile and are bisected by the median; the whiskers extend to the minimum and maximum value. P-values derived from Wilcoxon rank sum test. ǂ =P < 0.05. AKI, acute kidney injury; ICI, immune checkpoint inhibitors; IL, interleukin; KIM, kidney injury molecule; NGAL, neutrophil gelatinase-associated lipocalin.