Table 5.
Immune cell phenotype subgroups in kidney biopsies, by AKI cause
| Cell % | AKI-ICI (n = 4) | AKI-Other (n = 4) | P-value |
|---|---|---|---|
| CD4 memory T cells | 3.10 (1.77, 5.39) | 0.25 (0.11, 0.40) | 0.021a |
| CD4 naïve T cells | 0.17 (0.02, 0.40) | 0.01 (0.01, 0.01) | 0.19 |
| CD8 memory T cells | 0.97 (0.57, 1.18) | 0.15 (0.11, 0.17) | 0.25 |
| CD8 naïve T cells | 0.03 (0.01, 0.06) | 0.01 (0.00, 0.05) | 0.77 |
| T helper subset | 5.57 (3.04, 8.18) | 0.30 (0.18, 0.46) | 0.021a |
| T cytotoxic subset | 1.19 (0.60, 1.66) | 0.19 (0.14, 0.24) | 0.25 |
| T reg cells | 1.16 (0.40, 2.89) | 0.10 (0.06, 0.16) | 0.15 |
| B cells | 0.16 (0.01, 0.40) | 0.00 (0.00, 0.02) | 0.24 |
| Dendritic cells | 0.74 (0.31, 1.92) | 0.04 (0.03, 0.12) | 0.043a |
| Macrophages | 0.00 (0.00, 0.00) | 0.00 (0.00, 0.00) | 0.85 |
| NK cells | 0.00 (0.00, 0.01) | 0.01 (0.00, 0.01) | 0.55 |
AKI, acute kidney injury; ICI, immune checkpoint inhibitor; NK cells, natural killer cells.
Summary statistics reported are median (IQR). P-values are derived from the Wilcoxon rank sum test.
a
Statistical significance at the 0.05 α-level.