Table 2.
Histologic findings in ICI-related and non-ICI related AIN
| Finding | ICI-related n = 11 | Non-ICI related n = 12 | P-value |
|---|---|---|---|
| Cortical tissue affected (%) | 50 (50–60) | 25 (20–25) | < 0.001 |
| Interstitial inflammatory cells other than lymphocytes | |||
| Eosinophils | 7 (64%) | 6 (50%) | 0.41 |
| Plasma cells | 5 (45%) | 3 (25%) | 0.40 |
| Histiocytes | 5 (45%) | 3 (25) | 0.40 |
| Tubulitis moderate and severe | 7 (64%) | 3 (25) | 0.09 |
| IFTA <25% | 8 (72%) | 10 (83%) | 0.64 |
| IHC | |||
| PD1 | 10 (91%) | 1 (9%) | < 0.001 |
| PDL1PD-L1 | 10 (91%) | 1 (9%) | < 0.001 |
AIN, acute tubulointerstitial nephritis; ICI, immune checkpoint inhibitors; IFTA, interstitial fibrosis and tubular atrophy; IHC, immunohistochemistry