Table 5.
Baseline clinical characteristics (at the time of symptoms onset) and histopathology
| ID | Age (yr)/sex | Serum creatinine (μmol/ml)/eGFR (ml/min) | Upn | Upc | Urc | Hb (g/dl) | Serum Na+/K+ (mmol/l) | Serum Ca2+/PO43− (mg/dl) | Serum UA (mg/dl)/Pn (total) (g/dl) | BP (mm Hg) | Kidney size R/L (cm) | Histologic finding | EM findings: FP, DTC, MS, MB, AL, V (0 = absent; 1 = rare/small lysosomes only; 2 = frequent/dysmorphic lysosomes; # = no glomeruli in section) |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | 38/M | 196/26.52 | Plus | 1–2 | Nil | 14.7 | 142.6/4.22 | 9.89/1.46 | 6.91/7.7 | 120/80 | 10.9 × 4.7/10.0 × 5.5 | Mild chronic interstitial nephritis AI-1 CI-1 |
FP-0, DTC-0, MS-2, MB-2, AL-2, V-1 |
| 2 | 44/M | 128/42.09 | Trace | 1–2 | Nil | 12.7 | 144.7/4.18 | 8.97/2.4 | 5.46/7.4 | 121/81 | 9.0 × 4.3/9.3 × 4.8 | Chronic interstitial nephritis AI-1 CI-2 |
FP-1, DTC-0, MS-2, MB-0, AL-0, V-2 |
| 3 | 58/M | 128/40 | Trace | 8–10 | Nil | 14.3 | 9.52/1.14 | 6.19/7.81 | 118/79 | 9.1 × 4.6/9.1 × 4.7 | Mild chronic interstitial nephritis AI-1 CI-1 |
FP-2, DTC-1, MS-0, MB-0, AL-2, V-1 | |
| 4 | 60/M | 126/40.24 | Nil | occ | 2–4 | 13.9 | 125/81 | Mild interstitial fibrosis AI-0 CI-1 |
FP-1, DTC-1, MS-2, MB-2, AL-2, V-1 | ||||
| 5 | 53/M | 173/28.63 | Plus | occ | 8–10 | 12.6 | 142/3.6 | 8.9/1.58 | 6.54/7.07 | 119/79 | 8.8 × 5.1/9.5 × 4.5 | Chronic interstitial fibrosis AI-0 CI-2 |
FP-0, DTC-2, MS-2, MB-2, AL-2, V-2 |
| 6 | 49/M | 193/26 | 14.4 | 139/3.29 | 110/70 | 9.9 × 4.2/10.4 × 4.7 | Mild chronic interstitial nephritis AI-1 CI-1 |
FP-0, DTC-2, MS-1, MB-0, AL-2, V-2 | |||||
| 7 | 54/M | 321/13.97 | Plus | 100–150 | 1–2 | 13.2 | 119/80 | 10.9 × 4.3/10.4 × 4.5 | Mild chronic interstitial nephritis AI-1 CI-1 |
FP-0, DTC-2, MS-2, MB-2, AL-1, V-2 | |||
| 8 | 55/M | 169/29.19 | Trace | 30–40 | 2–3 | 118/75 | 9.1 × 4.8/9.7 × 5.8 | Mild chronic interstitial nephritis AI-1 CI-1 |
FP-1, DTC-2, MS-1, MB-0, AL-2, V-2 | ||||
| 9 | 40/M | 90/64.43 | Nil | 4–5 | Nil | 15 | 139/3.6 | 5.7/NA | 120/85 | Mild chronic interstitial nephritis AI-1 CI-1 |
FP-#, DTC-1, MS-0, MB-0, AL-2, V-1 | ||
| 10 | 32/M | 220/24 | Plus | 60–70 | 2–3 | 137.7/3.44 | 7.05 | 5.95/NA | 119/72 | 11.3 × 4.5/11.9 × 4.9 | Acute on chronic interstitial nephritis AI-2 CI-2 |
FP-#, DTC-0, MS-2, MB-0, AL-1, V-2 | |
| 11 | 61/F | 248/18 | Trace | 5–8 | 12.6 | 9.58/1.43 | 5.41/8.81 | 118/81 | 10.1/10 | Acute tubular injury AI-1 CI-0 |
FP-#, DTC-2, MS-1, MB-1, AL-0, V-2 | ||
| 12 | 33/M | 170/32 | 13.2 | 120/85 | 10.1 × 5.9/9.6 × 5.7 | Chronic interstitial nephritis AI-1 CI-2 |
FP-0, DTC-1, MS-0, MB-2, AL-2, V-1 | ||||||
| 13 | 62/M | 218/21 | Trace | 30–40 | Nil | 12.5 | 140.7/5.47 | NA/7.7 | 119/79 | 10.6 × 4.4/11.4 × 5.4 | Mild chronic interstitial nephritis AI-1 CI-1 |
FP-#, DTC-0, MS-1, MB-2, AL-1, V-2 |
AI, activity index; AL, altered lysosomes; BP, blood pressure; CI, chronicity index; DTC, detached tubular cell; eGFR, estimated glomerular filtration rate; EM, electron microscopy; FP, foot process; Hb, hemoglobin; ID, identification; L, left kidney; M, male; MB, myeloid body; MS, mitochondrial swelling; NA, not available; Pn, protein; R, right kidney; UA, uric acid; Upc, urinary pus cell; Upn, urinary protein; Urc, urinary red cell; V, vacuolization.