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. 2023 Mar 13;25(3):381–389. doi: 10.1038/s41556-023-01095-y

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a–c, Enriched pathways in CIART^−/− hPSC-AWOs (a), hPSC-ALOs (b) and hPSC-CMs (c) relative to their WT counterparts. The B-H p-value was corrected by the Benjamini-Hochberg method. The text in blue highlights that the RXR signaling pathway was enriched in CIART^−/− AWOs, ALOs and CMs. d–f, Heatmap of RXR pathway-associated genes comparing WT and CIART^−/− hPSC-AWOs (d), hPSC-AWOs (e) and hPSC-CMs (f). g, Relative expression levels of SARS-CoV-2 RNA in hPSC-CMs treated with DMSO, HX531 or PA452 (24 h.p.i.; m.o.i. = 0.3). h,i, Representative confocal images (h) and calculated percentages (i) of SARS-N⁺ cells in the cTnT⁺ subsets of hPSC-CMs treated with DMSO, HX531 or PA452 (24 h.p.i.; m.o.i. = 0.3). j, Relative expression levels of SARS-CoV-2 RNA in hPSC-AWOs treated with DMSO, HX531 or PA452 (24 h.p.i.; m.o.i. = 0.3). k,l, Representative confocal images (k) and calculated percentages (l) of SARS-N⁺ cells within the FOXJ1⁺ cell populations of hPSC-AWOs treated with DMSO, HX531 or PA452 (24 h.p.i.; m.o.i. = 0.3). m, Relative expression levels of SARS-CoV-2 RNA in hPSC-ALOs treated with DMSO, HX531 or PA452 (24 h.p.i.; m.o.i. = 0.3). n,o, Representative confocal images (n) and calculated percentages (o) of SARS-N⁺ cells within the mature SP-B⁺ cell populations of hPSC-ALOs treated with DMSO, HX531 or PA452 (24 h.p.i.; m.o.i. = 0.3). p,q, Representative confocal images (p) and calculated percentages (q) of SARS-N⁺ cells within the mature SP-C⁺ cell populations of hPSC-ALOs treated with DMSO, HX531 or PA452 (24 h.p.i.; m.o.i. = 0.3). Data are presented as an integration of all biological replicates (a–c), individual biological replicates (d–f) or the mean ± s.d. (g,i,j,l,m,o,q); n = 3 independent biological replicates. P values were calculated using a paired or an unpaired two-tailed Student’s t-test. Scale bars, 100 μm.

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