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. 2023 Mar 1;11:1129538. doi: 10.3389/fbioe.2023.1129538

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Copyright © 2023 Ge, Wang, Lin, Tao, Xia, Wang, Mao and Feng.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The miR-132-exo promoted angiogenesis and vascular network formation in diabetic wounds. (A) Representative laser Doppler images on postsurgery day 3, 7, and 14; (B) Representative co-staining images of α-SMA and CD31 positive microvessels in each group on day 14, scale bar = 50 μm; (C) Representative immunofluorescence staining images of ZO-1 (red) and α-SMA (green) co-staining in each group on day 14, scale bar = 100 μm; (D) Quantitative data of signal intensity of blood flow in diabetic wounds in each group; (E) Quantification of newly formed vessels per field corresponding to co-staining of α-SMA and CD31; (F) Quantification of mean fluorescence intensity per field corresponding to co-staining of ZO-1 and α-SMA. *p < 0.05, **p < 0.01, ***p < 0.001, data are presented as the mean ± SD, n = 3.