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. 2023 Mar 1;17:1130205. doi: 10.3389/fncel.2023.1130205

FIGURE 1.

FIGURE 1

Summary of effects of NPCs on microglia fates. (A) Effects of transplantation of exogenous NPCs on microglial abundance and reactive states in various inflammation and disease models. Increase in total or M1-like/M2-like microglia abundance within a model is indicated with an upward green arrow, decrease is indicated with a downward red arrow. (B) Endogenous role of NPCs on microglia activity and localization via ablation of NPCs in vivo or addition of NPCs in vitro. (C) Factors and pathways originating in NPCs that have specific effects on microglial reactivity and functions. Please see text for details and references. This figure was generated using BioRender and Adobe Illustrator. NPC, neural precursor cell; EAE, experimental autoimmune encephalomyelitis; CM, conditioned media; SVZ, subventricular zone; VZ, ventricular zone.