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. 2023 Mar 1;17:1123817. doi: 10.3389/fnins.2023.1123817

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Copyright © 2023 Chi, Wang, Liu, Zhang and Shen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Synaptic plasticity can be categorized into structural synaptic plasticity (A) and functional synaptic plasticity (B). Structural synaptic plasticity panel (A) refers to the number, density, distribution of synapses, and highlights the strength of synaptic connections. Functional synaptic plasticity panel (B) refers to the efficiency of synaptic transmission, and includes NMDAR-dependent LTP and NMDAR-dependent LTD. GAP-43, PSD-95, Syn, CaMKII, NMDAR, and AMPAR are synaptic plasticity-related proteins, which play important roles in mediating changes in synaptic morphology, structure, and density and in the function of inter-synaptic information transfer.