Table 2.
Univariable and Multivariable Cox Proportional Hazard Model for all-Cause 1-Year Mortality.
| Variable | Univariable HR (95%CI) | P value | Multivariable HR (95%CI) | P value |
|---|---|---|---|---|
| Age | 1.02 (1.01-1.05) | .009 | NS | |
| BMI | 0.94 (0.9-0.98) | .006 | NS | |
| BNP | 1.01 (1.001-1.01) | .01 | NS | |
| Troponin | 1.1 (1.1-1.2) | <.001 | NS | |
| CHF | 2.2 (1.1-4.6) | .04 | NS | |
| CKD | 2.2 (1.0-4.9) | .04 | NS | |
| Prior PE | 2.1 (1.0-4.2) | .05 | NS | |
| PAI-1/TAFI/A2A Group 1 (as compared to Group 0) |
1.4 (0.5-3.9) | .58 | 2.1 (0.4-10.5) | .35 |
| PAI-1/TAFI/A2A Group 2 (as compared to Group 0) |
3.1 (1.1-8.6) | .03 | 6 (1.3-27.8) | .02 |
| PAI-1/TAFI/A2A Group 3 (as compared to Group 0) |
9.3 (2.7-32.1) | <.001 | 12 (1.7-86) | .013 |
| Cancer | 5 (2.7-9.6) | <.001 | 2.7 (1.1-6.6) | .03 |
| PESI (per 10 point increase) | 1.2, (1.1-1.3) | <.001 | 1.1 (1-1.2) | .01 |
| PE severity (per increase in group severity: Low, submassive, and massive) | 1.6 (0.9-2.8) | .09 | 0.44 (0.18-1.1) | .07 |
| Lactate (per 1 point increase) | 1.2 (1.2-1.3) | <.001 | 1.3 (1-1.7) | .02 |
Abbreviations: PE, pulmonary embolism; BMI, body mass index; PESI, pulmonary embolism severity index; CKD, chronic kidney disease; CHF, congestive heart failure; BNP, brain natriuretic peptide; PAI, plasminogen activator inhibitor; TAFI, thrombin activatable fibrinolysis inhibitor; A2A, alpha 2 antiplasmin.