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Sample size estimates for observing time-related differences in troglitazone (180 μM) toxicity in experiments with OrganoPlate® 2-lane 96 plate seeded with iHeps and non-parenchymal cells. Shown are the number of paired devices needed for detecting significant (p<0.05 with 80% power) differences at each timepoint.
| Endpoint | 24 h | 48 h | 72 h |
|---|---|---|---|
|
| |||
| Live cells (%) | 6 (3/group) | ||
| Lactate dehydrogenase | 8 | 6 | 4 |
| Albumin | 30 | 9 | 5 |
| Urea | 41 | >100 | 7 |
