Table 1.
Baseline characteristics.
| Amantadine (n = 95) | Placebo (n = 91) | p-valuea | |
|---|---|---|---|
| Female | 33 (34.7%) | 36 (39.6%) | 0.545 |
| Age group | 0.122 | ||
| <45 years | 17 (17.9%) | 24 (26.4%) | n/a |
| 45–64 | 39 (41.1%) | 42 (46.2%) | |
| >65 | 39 (41.1%) | 25 (27.5%) | |
| BMI, mean (SD) | 27.8 (4.6) | 29 (5.7) | 0.198 |
| Remdesivir | 46 (48.4%) | 49 (53.8%) | 0.467 |
| Convalescent plasma | 1 (1.1%) | 0 (0%) | 1 |
| Symptoms at baseline (ordinal scale) | 0.682 | ||
| 4 | 4 (4.2%) | 2 (2.2%) | n/a |
| 5 | 91 (95.8%) | 89 (97.8%) | |
| Time from symptom onset to randomisation, mean (SD) | 6.7 (2.4) | 6.8 (2.1) | 0.731 |
| Fever | 65 (68.4%) | 66 (72.5%) | 0.650 |
| Cough | 56 (58.9%) | 61 (67%) | 0.322 |
| Dyspnoea | 70 (73.7%) | 67 (73.6%) | 1 |
| Abnormal smell or taste | 11 (11.7%) | 11 (12.1%) | 1 |
| Myalgia | 17 (18.1%) | 20 (22.2%) | 0.605 |
| Chest pain | 7 (7.4%) | 6 (6.6%) | 1 |
| Diarrhoea | 8 (8.5%) | 11 (12.1%) | 0.576 |
| Nausea | 3 (3.2%) | 6 (6.6%) | 0.463 |
| Vomiting | 2 (2.1%) | 5 (5.5%) | 0.415 |
| Sore throat | 5 (5.3%) | 5 (5.5%) | 1 |
| Nasal hyperaemia | 6 (6.4%) | 3 (3.3%) | 0.526 |
| Electrocardiography | 0.467 | ||
| Normal | 59 (63.4%) | 63 (69.2%) | n/a |
| Clinically irrelevant abnormalities | 33 (35.5%) | 28 (30.8%) | |
| Clinically relevant abnormalities | 1 (1.1%) | 0 (0%) | |
| Diabetes | 25 (26.3%) | 18 (19.8%) | 0.302 |
| Hypertension | 39 (41.1%) | 42 (46.2%) | 0.554 |
| Obesity | 25 (26.3%) | 31 (34.1%) | 0.321 |
| Chronic respiratory disease | 11 (11.6%) | 11 (12.1%) | 1 |
| Sleep apnoea | 2 (2.1%) | 0 (0%) | 0.496 |
| Coronary heart disease | 8 (8.4%) | 5 (5.5%) | 0.568 |
| Other cardiovascular disease | 11 (11.6%) | 7 (7.7%) | 0.459 |
| Dyslipidaemia | 9 (9.5%) | 5 (5.5%) | 0.407 |
| Hypothyroidism | 3 (3.2%) | 8 (8.8%) | 0.127 |
| Comorbidities | |||
| None | 38 (40%) | 31 (34.1%) | 0.224 |
| 1 | 19 (20%) | 22 (24.2%) | |
| 2 | 19 (20%) | 27 (29.7%) | |
| 3 or more | 19 (20%) | 11 (12.1%) |
a
Chi-squared test or Wilcoxon test; values show counts of patients (percentages) if not specified otherwise; BMI – body mass index; n/a – non applicable; SD, standard deviation.