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. 2023 Mar 14;8:116. doi: 10.1038/s41392-023-01343-5

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — The milestone events for cellular rejuvenation research advances. Starting with the 1934 discovery of the influence of dietary restriction on lifespan extension, important findings on the subject of cellular rejuvenation are emphasized. More recently, the senolytics development and reprogramming technology have been widely applied for cellular rejuvenation. rhEGF recombinant human epidermal growth factor, iPSCs induced pluripotent stem cells, AMPK 5’-AMP-activated protein kinase, NF-κB nuclear factor-κB, STAT3 signal transducer and activator of transcription 3, mTOR mammalian target of rapamycin. Created with BioRender.com