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. 2023 Mar 14;8:116. doi: 10.1038/s41392-023-01343-5

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — Reprogramming approaches for rejuvenation. The iPSC-mediated cell reprogramming is a protocol that somatic cells are first dedifferentiated into iPSC and then differentiated into the desired somatic cells. Partial reprogramming refers to a short exposure to Yamanaka factors only generates intermediates with high plasticity. Transforming somatic cells from one lineage to another without transitioning through intermediary pluripotent stages is known as direct lineage reprogramming. iPSCs induced pluripotent stem cells, ESCs embryonic stem cells; Oct3/4, Sox2, Klf4, c-Myc, OSKM. Created with BioRender.com