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. 2023 Mar 13;2023(3):CD010941. doi: 10.1002/14651858.CD010941.pub3

Comparison 4. Individual tailored versus continuous tapered dexamethasone regimen.

Outcome or subgroup title No. of studies No. of participants Statistical method Effect size
4.1 Death or bronchopulmonary dysplasia at 36 weeks PMA 3 168 Risk Ratio (M‐H, Fixed, 95% CI) 1.06 [0.88, 1.29]
4.2 Mortality at 28 days PNA 2 109 Risk Ratio (M‐H, Fixed, 95% CI) 2.83 [0.60, 13.32]
4.3 Mortality at 36 weeks PMA 3 168 Risk Ratio (M‐H, Fixed, 95% CI) 1.54 [0.63, 3.79]
4.4 Mortality at hospital discharge 3 168 Risk Ratio (M‐H, Fixed, 95% CI) 1.84 [0.77, 4.37]
4.5 Bronchopulmonary dysplasia at 28 days PNA 2 109 Risk Ratio (M‐H, Fixed, 95% CI) 1.15 [0.88, 1.50]
4.6 Bronchopulmonary dysplasia at 36 weeks PMA 3 168 Risk Ratio (M‐H, Fixed, 95% CI) 0.99 [0.79, 1.25]
4.7 Failure to extubate 3 days after initiation 1   Risk Ratio (M‐H, Fixed, 95% CI) Totals not selected
4.8 Failure to extubate 7 days after initiation 1   Risk Ratio (M‐H, Fixed, 95% CI) Totals not selected
4.9 Days of mechanical ventilation 2 90 Mean Difference (IV, Fixed, 95% CI) 9.26 [4.32, 14.21]
4.10 Days on supplemental oxygen 1   Mean Difference (IV, Fixed, 95% CI) Totals not selected
4.11 Hypertension 2 135 Risk Ratio (M‐H, Fixed, 95% CI) 0.34 [0.01, 8.13]
4.12 Hyperglycemia 2 98 Risk Ratio (M‐H, Fixed, 95% CI) 0.66 [0.26, 1.66]
4.13 Open‐label corticosteroids 2 135 Risk Ratio (M‐H, Fixed, 95% CI) 1.72 [0.72, 4.13]
4.14 Culture confirmed infection 2 92 Risk Ratio (M‐H, Fixed, 95% CI) 1.27 [0.58, 2.76]
4.15 Necrotizing enterocolitis 2 98 Risk Ratio (M‐H, Fixed, 95% CI) 1.75 [0.48, 6.35]
4.16 Intraventricular hemorrhage (> grade II) 3 168 Risk Ratio (M‐H, Fixed, 95% CI) 2.00 [0.78, 5.18]
4.17 Periventricular leucomalacia 1   Risk Ratio (M‐H, Fixed, 95% CI) Totals not selected
4.18 Retinopathy of prematurity (any) 2 98 Risk Ratio (M‐H, Fixed, 95% CI) 0.83 [0.24, 2.92]
4.19 Cerebral palsy in survivors assessed at 1‐3 years 1   Risk Ratio (M‐H, Fixed, 95% CI) Totals not selected
4.20 Death or cerebral palsy at 1‐3 years 1   Risk Ratio (M‐H, Fixed, 95% CI) Totals not selected
4.21 Bayley's MDI < ‐2 SD 1   Risk Ratio (M‐H, Fixed, 95% CI) Totals not selected
4.22 Severe blindness 1   Risk Ratio (M‐H, Fixed, 95% CI) Totals not selected
4.23 Abnormal neurodevelopmental outcome in survivors assessed (various definitions) 3 143 Risk Ratio (M‐H, Fixed, 95% CI) 1.09 [0.71, 1.70]
4.24 Death or abnormal neurodevelopmental outcome (various definitions) 3 168 Risk Ratio (M‐H, Fixed, 95% CI) 1.44 [0.99, 2.07]