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. 2023 Mar 13;2023(3):CD010941. doi: 10.1002/14651858.CD010941.pub3

Da Silva 2002.

Study characteristics
Methods Single center double‐blind randomized trial on moderate‐ versus low‐dosage regimen of dexamethasone.
Participants Extremely low birth weight infants (≤ 1500 grams), initial starting administration between 7 and 21 days.
Interventions The included infants were randomly assigned to 1 of 2 dosage regimens.
  1. A moderate‐dosage regimen with an unknown cumulative dose of dexamethasone administered over a 7‐day course, starting with 0.5 mg/kg/day, and then tapered during 7 days with unknown schedule.

  2. A low‐dosage regimen with a cumulative dose of 0.7 mg/kg administered over 7 days: 0.1 mg/kg/day for 7 days

Outcomes Primary outcomes were growth parameters (weight, length and head circumference) at 36 weeks' corrected gestational age. Secondary outcomes were documented sepsis and long‐term growth parameters at 9 months of corrected age (actual numbers not provided).
Notes Funding: no statement.
Declarations of interest: not reported.
Trial was only published as an abstract and original authors could not provide any additional data.
Risk of bias
Bias Authors' judgement Support for judgement
Random sequence generation (selection bias) Unclear risk Not described in abstract.
Allocation concealment (selection bias) Unclear risk Not described in abstract.
Blinding of participants and personnel (performance bias)
All outcomes Low risk Stated in the abstract as being double blinded, actual procedure not described.
Blinding of outcome assessment (detection bias)
All outcomes Low risk Stated in the abstract as being double blinded, actual procedure not described.
Incomplete outcome data (attrition bias)
All outcomes Unclear risk Unknown.
Selective reporting (reporting bias) Unclear risk Unknown.
Other bias Unclear risk Unknown.