Severe plasma leakage or shock	Severe dengue defined as (1) severe plasma leakage or shock; OR (2) severe bleeding; OR (3) severe organ impairment
	Shock OR respiratory distress AND plasma leakage
	Shock, any of 3 criteria: 1. Shock listed in medical assessment at any time 2. Use of vasopressors, inotropics, or vasodilators; use of albumin 3. Pulse pressure <20 mmHg OR hypotension OR drop in systolic blood pressure >40 mmHg AND any 2 of the following:  Elevated heart rate  Capillary refill > 2 seg  Mottled skin  Thready, weak pulse  Pale and/or cold skin  Blue skin or lips  Cyanotic limbs  Cold limbs	Respiratory distress and plasma leakage, both criteria: 1. Respiratory compromise: any of the following  Tachypnea  Respiratory distress  Accessory muscles use  Supplemental oxygen  Intubation 2. Plasma leakage: any of the following  Pleural effusion  Pericardial effusion  Ascites  Free fluid in abdomen  Hematocrit change >20% during illness  Hematocrit value >20% above baseline for age and sex at any time  Albumin low for age
Severe bleeding	Any of the following:  Blood transfusion  Hematochezia  Melena  Hematemesis
Severe organ involvement	Any of the following:  AST or ALT ≥ 1000 U  Intubation/mechanical ventilation  PT INR ≥ 1.5  Encephalopathy  Myocarditis  Acute hepatitis  Glasgow score <11  Aseptic meningitis  Acute paralysis