Table 1.
Characteristics | Cluster 1 | Cluster 2 | Cluster 3 | Cluster 4 | P-value |
---|---|---|---|---|---|
N | 346 | 468 | 329 | 115 | |
Duration of attempt to conceive, years | 3.0 [2.0, 6.0] | 3.0 [2.0, 6.0] | 4.0 [2.0, 5.0] | 4.0 [2.0, 6.0] | 0.521 |
Male age, years | 32.0 [30.0, 35.0] | 33.0 [30.0, 36.0] | 33.0 [31.0, 37.0] | 36.0 [31.5, 39.5] | < 0.001 |
Female age, years | 31.0 [28.0, 33.0] | 31.0 [29.0, 34.0] | 31.00 [29.0, 34.0] | 32.00 [30.0, 35.0] | 0.003 |
Male BMI, kg/m2 | 23.5 [21.2, 25.9] | 23.7 [21.7, 26.1] | 23.3 [21.3, 25.6] | 23.5 [21.3, 26.5] | 0.534 |
Female BMI, kg/m2 | 21.9 [20.0, 23.9] | 21.7 [20.0, 23.9] | 21.8 [20.3, 23.6] | 22.1 [20.8, 23.9] | 0.377 |
Sperm DNA fragmentation index, % | 8.6 [6.4, 12.5] | 12.4 [8.8, 17.1] | 15.9 [11.4, 20.2] | 36.4 [30.1, 43.3] | < 0.001 |
Semen volume, mL | 3.1 [2.3, 4.0] | 2.9 [2.1, 3.8] | 3.0 [2.1, 4.0] | 2.9 [2.1, 4.2] | 0.182 |
Sperm concentration, 106 / ml | 62.0 [46.9, 87.3] | 55.1 [38.1, 78.4] | 29.30 [19.3, 41.8] | 32.00 [20.6, 52.6] | < 0.001 |
Rapidly progressive motility, % | 51.5 [47.0, 56.0] | 36.0 [31.0, 40.0] | 19.0 [14.0, 25.0] | 13.0 [6.5, 20.0] | < 0.001 |
Slow or sluggish progressive motility, % | 19.0 [17.0, 22.0] | 22.0 [18.0, 26.0] | 14.0 [10.0, 17.0] | 12.0 [7.5, 15.0] | < 0.001 |
Anti-Mullerian hormone, ng/ml | 4.1 [2.6, 6.2] | 3.9 [2.4, 6.4] | 3.7 [2.6, 6.2] | 3.8 [2.6, 5.6] | 0.783 |
Estradiol, pmol/L | 117.5 [83.4, 174.3] | 126.0 [88.0, 178.0] | 125.0 [87.0, 171.0] | 121.0 [93.0, 154.5] | 0.681 |
Follicle-stimulating hormone, mIU/ml | 5.4 [4.6, 6.1] | 5.2 [4.5, 6.1] | 5.2 [4.3, 6.3] | 5.5 [4.8, 6.3] | 0.217 |
Endometrial thickness on hCG trigger day, mm | 10.7 [9.5, 11.6] | 10.7 [9.5, 11.8] | 10.7 [9.3, 12.0] | 10.7 [9.5, 12.0] | 0.679 |
Number of long down-regulation protocol | 234 (67.6) | 326 (69.7) | 224 (68.1) | 78 (67.8) | 0.927 |
Number of oocytes retrieved | 11.0 [8.0, 14.0] | 11.0 [8.0, 14.0] | 11.0 [8.0, 14.0] | 10.0 [8.0, 14.0] | 0.854 |
Number of fertilized eggs | 9.0 [6.0, 11.0] | 9.0 [6.0, 12.0] | 8.0 [6.0, 11.0] | 7.0 [6.0, 11.0] | 0.006 |
Number of oocytes cleaved | 9.0 [6.0, 11.0] | 9.0 [6.0, 12.0] | 8.00 [6.0, 11.0] | 7.00 [5.0, 10.0] | 0.003 |
Number of embryos available on Day3 | 4.0 [2.0, 7.0] | 5.0 [3.0, 7.0] | 4.0 [2.0, 6.0] | 4.0 [2.0, 5.0] | 0.012 |
Fertilization rate, % | 87.5 [75.0, 100.0] | 87.5 [73.3, 100.0] | 83.3 [66.7, 93.8] | 80.0 [60.0, 88.9] | < 0.001 |
Cleavage rate, % | 100.0 [100.0, 100.0] | 100.0 [100.0, 100.0] | 100.0 [100.0, 100.0] | 100.0 [100.0, 100.0] | 0.490 |
D3 available embryos rate, % | 50.0 [31.8, 70.0] | 54.5 [33.3, 75.0] | 50.00 [28.6, 70.0] | 57.1 [31.7, 71.4] | 0.592 |
Abbreviation: BMI body mass index. Note: Values are median (interquartile range) or number (%)