Table 2.
The crude and multi-variate adjusted odds ratios (95% CIs) of IVF outcomes in relation to the multi-variable co-exposure clusters
| Cluster | Events/patients | Crude model | Model 1a | Model 2b |
|---|---|---|---|---|
| Live birth outcome | ||||
| Cluster 1c | 165/346 | ref | ref | ref |
| Cluster 2d | 215/468 | 0.932 (0.706, 1.232) | 0.940 (0.710, 1.244) | 0.933 (0.704, 1.236) |
| Cluster 3e | 129/329 | 0.708 (0.521, 0.960) | 0.734 (0.539, 0.998) | 0.733 (0.537, 0.998) |
| Cluster 4f | 40/115 | 0.585 (0.375, 0.902) | 0.618 (0.394, 0.959) | 0.620 (0.394, 0.967) |
| Clinical pregnancy outcome | ||||
| Cluster 1c | 190/346 | ref | ref | ref |
| Cluster 2d | 255/468 | 0.983 (0.743, 1.299) | 0.984 (0.743, 1.302) | 0.984 (0.742, 1.303) |
| Cluster 3e | 153/329 | 0.714 (0.527, 0.966) | 0.718 (0.529, 0.974) | 0.720 (0.530, 0.977) |
| Cluster 4f | 48/115 | 0.588 (0.382, 0.899) | 0.590 (0.381, 0.908) | 0.592 (0.381, 0.914) |
| β-hCG positive outcome | ||||
| Cluster 1c | 197/346 | ref | ref | ref |
| Cluster 2d | 256/468 | 0.913 (0.690, 1.208) | 0.915 (0.690, 1.212) | 0.913 (0.689, 1.211) |
| Cluster 3e | 161/329 | 0.725 (0.535, 0.981) | 0.731 (0.539, 0.992) | 0.733 (0.539, 0.995) |
| Cluster 4f | 50/115 | 0.582 (0.379, 0.889) | 0.585 (0.379, 0.900) | 0.587 (0.379, 0.906) |
Note:
aModel 1 was adjusted for duration of attempt to conceive, female age, male age, female BMI, and male BMI
bModel 2 was additionally adjusted for controlled ovulation stimulation protocols, AMH, E2, FSH, endometrial thickness, and numbers of oocytes retrieved
cLow-level DFI/high-level semen parameter group
dLow-level DFI/median-level semen parameter group
eLow-level DFI/low-level semen parameter group
fHigh-level DFI/low-level semen parameter group
Bold demonstrates statistical significance