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Exosome release delays senescence by disposing of obsolete biomolecules. Exosome release from cells was closely correlated with a senescent phenotype both in vitro and in vivo. Inhibition of exosome release accelerated, while stimulation of exosome secretion delayed cell senescence and organism aging. Increased exosome secretion by nutrient restriction or rapamycin allows the excretion of harmful biomolecules which can be disposed of by professional “cleaners”, such as macrophages.
