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. 2023 Jan 22;10(8):2205668. doi: 10.1002/advs.202205668

Figure 2.

Figure 2

CircWDR37 deficiency inhibits the metastasis of chemotherapy‐induced senescent NPC cells in vitro. a) Representative images and quantified results of the transwell migration and invasion assays in S18, HONE1, and HK1 cells transfected with si‐circWDR37 or siSCR. b) Representative images and quantified results of the colony formation assay in si‐circWDR37 or siSCR transfected HONE1 and HK1 cells with cisplatin or gemcitabine treatment. DDP, Cisplatin; Gem, gemcitabine. c) Representative images and quantified results of SA‐β‐gal staining si‐circWDR37 or siSCR transfected HONE1 cells with cisplatin or gemcitabine treated for 24 h. d) Western blots analysis of senescence marker p16 in si‐circWDR37 or siSCR transfected HONE1, S18, and HK1 cells with cisplatin or gemcitabine treated for 24 h. e) Representative images and quantified results of the transwell migration and invasion assays in si‐circWDR37 or siSCR transfected HONE1 and HK1 cells with cisplatin or gemcitabine treated for 24 h. Mean (n = 3) ± s.d. (Data were analyzed by (a, b, c, e) one‐way ANOVA with Dunnett's post‐hoc test). p‐value < 0.05 indicates statistical significance. N.S. indicates no significance. Scale bar, 200 µm.