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. 2023 Jan 22;10(8):2205668. doi: 10.1002/advs.202205668

Figure 7.

Figure 7

CircWDR37 deficiency impairs NPC cell metastasis in vivo. a) Representative images of footpad tumors after S18 cells with sh‐circWDR37 stable expression or its scramble control injected into the food pads of nude mice. b) Representative microscopy images of footpad tumors. c) Image and d) quantification of the volumes of the inguinal lymph nodes. e) Representative images of pan‐cytokeratin positive inguinal lymph nodes and f) inguinal lymph node metastatic ratios. Mean (n = 7) ± s.d. g) Representative images and h) quantification of macroscopic metastatic nodules on lung surfaces. Mean (n = 5) ± s.d. i) Representative images and j) quantification of microscopy metastatic nodules on lung tissues. Mean (n = 5) ± s.d. k) Representative microscopy images of footpad tumors. l) Image and m) quantification of the volumes of the inguinal lymph nodes. n) Representative images of pan‐cytokeratin positive inguinal lymph nodes and o) inguinal lymph node metastatic ratios. Mean (n = 5) ± s.d. (Data were analyzed by (d, h, j, m) two‐tailed Student's t‐test and (f, o) Chi‐square test). p‐value < 0.05 indicates statistical significance. Scale bar, 200 µm.