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. 2023 Jan 22;10(8):2205668. doi: 10.1002/advs.202205668

Figure 8.

Figure 8

CircWDR37 high expression is associated with an adverse prognosis and a lack of responsiveness to induction chemotherapy in NPC patients. a) Kaplan–Meier analysis of disease‐free survival, b) distant metastasis‐free survival, and c) overall survival in patients with low circWDR37 expression (n = 39) and high circWDR37 expression (n = 101) groups. Forest plots of univariate analysis showing the significance of d) different prognostic variables in disease‐free survival, e) distant metastasis‐free survival, and f) overall survival of NPC patients. g) Representative images of magnetic resonance imaging (MRI) scans before and after induction chemotherapy in responder or non‐responder. NPC tumors are indicated by red lines. h) Bar plot representing the percentage of cases with circWDR37 high or low expression in clinical NPC patient samples from responders (R, n = 56) versus non‐responders (NR, n = 7). Kaplan–Meier analysis of i) disease‐free survival and j) distant metastasis‐free survival in induction chemotherapy responders with low circWDR37 expression (n = 40) and high circWDR37 expression (n = 16) groups. k) Proposed model of the mechanism underlying the function of circWDR37 in NPC cell metastasis and senescence resistance. (Data were analyzed by (a–c, i, j) log‐rank test, (d–f) cox proportional hazards regression model, and (h) Chi‐square test). p‐value < 0.05 indicates statistical significance.