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This study demonstrates an intravenous genetically engineered microparticle loaded with deubiquitin inhibitor, which is a substance derived from lung cancer cells treated with radiation therapy. Microparticles cross the blood‐brain barrier and target and reprogram M2 macrophages at the same time, promoting effector T cell infiltration and the release of pro‐inflammatory cytokines, effectively inhibiting the development of brain metastases of lung cancer.
