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. 2023 Mar 14;21:195. doi: 10.1186/s12967-023-04036-3

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© The Author(s) 2023

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 5 — LGG-SN in combination with Irinotecan (IRN) shows a synergistic effect in cancer cells. A. HT-29, HCT-116, Caco-2, A375 concentration response plots. Cells treated with IRN (from 3.1 × 10^–9 M to 2.0 × 10^–4 M) in combination with different LGG-SN concentrations (50% and 70% v/v). B. HT-29, HCT-116, Caco-2, A375 relative inhibition matrices (left), Highest Single Agent (HSA) synergy matrices (middle), synergy surface with most synergistic area (black square, with corresponding HSA synergy score). N = 3. Values are presented as Mean ± SD