Figure 5.

NGS analysis of serial of samples in two MDS patients who acquired SF3B1 mutations over the course of the disease: in patient #1, at the time of AML progression (A), and in patient #2, post HMA therapy at the time of morphologically persistent disease with genotype change corresponding to phenotypic acquisition of ring sideroblasts (B). Representative FISH plots from both cases showing clonal architecture at different time points. In both cases, mutations cleared following allogeneic stem cell transplantation.