Fig. 5.

Dynamics of changes induced by repeated stimulation. A) Experimental setup. Anesthetized animals received single-pulse electrical stimulation to the hindpaw before repeated stimulation (baseline) and after. B) Sensory evoked responses were tested every 15 min for 1.5 h after repeated stimulation. C) Average similarity index between early and late spatiotemporal evoked responses in a single animal (n = 30 trials). D) Average similarity between the early and late components of evoked responses for multiple mice (n = 8 animals, error bars represent SEM and stars represent statistically different to baseline trials, one-way ANOVA with Bonferroni correction). E) Average similarity of evoked patterns of activity during spontaneous activity measured up to 1.5 h after repeated stimulation across animals (same as F). F) Dynamics of the 2-component ratio using a mixture of Gaussians model. Error bars denote the SEM and stars denote trials that are significantly different to the baseline trials (ANOVA with Bonferroni correction, n = 90 trials). G) Dynamics of the Fail ratio between the early and late components for animals that received repeated stimulation (darker dots) and animals that did not receive repeated stimulation (lighter dots).