Figure 6.

Sensory experience-dependent changes to the patterns of evoked activity in awake mice. A) Experimental setup. Animals are head-fixed passively listening to tones (i) while brain activity is recorded in the auditory cortex (ii). B) Experimental protocol. Single 50-ms tone trials were recorded before and after 30 min of repeated auditory stimulation (red). C) Representative spatiotemporal pattern of trial-average evoked activity before (top row) and after (bottom row) repeated auditory stimulation for 1 mouse. D) Mean peak amplitude of the auditory evoked response during the early evoked response (left) and late evoked response (right), before and after (red dots) repeated auditory stimulation (colored lines represent sessions for 3 different animals. E) Similarity between the sensory-evoked template and early evoked responses (left) and late evoked responses (right) in awake animals before and after (red) repeated stimulation. Each session had 30 trials (n = 30) of auditory stimulation. Error bars denote SEM and stars denote P < 0.05, paired t-test.