Table 2.
Main effects of APOE-ε4 within networks.
| Network | Contrast | t-value | pFWE | Brain region | x | y | z |
|---|---|---|---|---|---|---|---|
| DMN (IC01) | ε4HET > ε3HMZ | 4.75 | <0.01 | ACC | 10 | 46 | 4 |
| tDMN-L (IC04) | ε4-additive | 4.12 | 0.02 | pMTG | −50 | −46 | 12 |
| eVIS (IC07) | ε4-recessive | 3.51 | 0.03 | IOG | 38 | −86 | −4 |
| LIM (IC15) | ε4-recessive | 3.43 | 0.04 | OFC | 34 | 62 | −12 |
| MTL-L (IC36) | ε4-additive | 3.11 | 0.04 | HC | −22 | 2 | −16 |
HC, hippocampus; IOG, inferior occipital gyrus; LIM, Limbic network; MTL-L, left medial temporal network; OFC, orbitofrontal cortex; pFWE, family-wise corrected P-value; tDNM-L, left temporal default mode network; ε3HMZ, homozygotes for APOE-ε3; ε4HET, heterozygotes for APOE-ε4.