Table 2:

List Of Top 10 Highest Ranked Variables In Each Lasso Model And Baseline to12-Month Change Score

	Model A					Model B
		Non- Cancer Controls (n=441)		Persistent CRCD1 (n=60)			Non-Declining Survivors (n=147)		Persistent CRCD (n=60)
Variable	Lasso Rank	Mean	SD	Mean	SD	Lasso Rank	Mean	SD	Mean	SD
Category Fluency Total	1	0.07	4.61	−1.62	4.71	1	0.38	4.55	−1.62	4.71
NAB List Learning Trial 3	2	0.26	1.90	−0.45	1.95	5	0.18	1.82	−0.45	1.95
NAB Driving Scenes	3	−1.79	7.05	−3.88	6.88	3	−1.16	7.61	−3.88	6.88
NAB Digit Span Forward Total	7	0.21	1.99	−0.53	1.55	2	0.34	1.91	−0.53	1.55
PCI Score Baseline	9	61.08	21.39	68.20	14.87	4	61.41	21.41	68.20	14.87
TIADL Ingredients Can 2 Time2	10	0.02	12.41	2.50	9.07	8	−0.54	13.40	2.50	9.07
FACIT-Fatigue	4	1.26	7.99	−2.02	8.90
NAB List A Immediate Raw Score	5	1.09	4.57	−0.30	3.90
COWAT A Intrusions2	6	−0.10	0.74	0.75	6.80
NAB List Learning Long Delay Forced Choice False Alarms2	8	−0.55	2.68	0.10	2.30
Trail Making Test B Time2						6	−7.03	31.57	0.96	33.54
NAB List Learning Long Delay Forced Choice Hits						7	0.13	1.45	0.40	1.37
NAB Figure Drawing Copy						9	−0.49	4.75	0.17	4.43
Category Fluency Perseverations2						10	0.06	1.23	−0.17	1.38

Shaded areas represent tests that were not top ranked for that model.

¹Persistent CRCD is defined as 3.7+ points decline on the FACT-Cog Perceived Cognitive Impairment (PCI) scale from pre-systemic therapy baseline to 12 months, with persistence to 24-months

²Higher scores indicate worse performance

NAB = Neuropsychological Assessment Battery; PCI – Perceived Cognitive Impairment; TIADL = Timed Instrumental Activities of Daily Living; FACIT = Functional Assessment of Chronic Illness Therapy; COWAT = Controlled Oral Word Association Test; CRCD=cancer-related cognitive decline