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. 2023 Mar 13;11(3):e006522. doi: 10.1136/jitc-2022-006522

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© Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See http://creativecommons.org/licenses/by-nc/4.0/.

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PGC-1α^S571A, but not NT-PGC1α, induces mitochondrial and immunologic changes within CAR-T cells. (A) Principal component analysis (PCA) of PGC-1α^S571A CARs. (B) Differential expressed genes on a volcano plot. FDR, false discovery rate genes with an FDR p value<0.05 were marked with red. (C, D) GSEA of PGC-1α^S571A CARs with heatmaps for the top differentially expressed genes in these pathways (E) PCA of NT-PGC-1α CARs (F) All genes that differed statistically in the NT-PGC-1α CARs versus WT CAR analysis. CAR, chimeric antigen receptors; PGC-1α, PPAR gamma coactivator 1α; WT, wild-type; GSEA, Gene Set Enrichment Analysis.