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. 2023 Mar 1;14:1147526. doi: 10.3389/fimmu.2023.1147526

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Copyright © 2023 Daamen, Wang, Bachali, Shen, Kingsmore, Robl, Grammer, Fu and Lipsky

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Expression of chronic risk locus genes is associated with disease severity and kidney tubule resistance in NZM2328 and R27 AGN mice. (A, B) Log₂ expression values of immune receptor genes in the Cgnz1 risk locus from glomeruli (A) and TI (B) of NZM2328 CTL, AGN, TGN, and CGN mice. (C) Linear regression between log₂ expression of Cgnz1 locus genes and GSVA scores of kidney tubule cells from the TI of R27 mice. All statistically significant correlations are shown. (D) Linear regression between log₂ expression of Cgnz1 locus genes from C and GSVA scores of kidney tubule cells from the TI of NZM2328 mice. All statistically significant correlations are shown. (E) Log₂ expression values Cgnz1 locus genes from C in the TI of NZM2328 CTL, AGN, TGN, and CGN mice. *p<0.05, **p<0.01, ***p<0.001, ****p<0.0001.