Fig. 6.

Maps of COVID-19-induced altered signalling pathway in each organ of K18-hACE2 mice and quantification alteration of specific molecules. A–E. Map of proteins in significantly altered signalling pathways in the cortex (A), hippocampus (B), thalamus (C), lung (D), and kidney (E) after SARS-CoV-2 infection. The pink to green colour gradient represents the log₂ FC of the proteins measured in each organ. F–G. Quantification of Stat1 (F) and Stat1-S727 (G) in five organs of K18-hACE2 mice. ∗P < 0.05, ∗∗P < 0.01, ∗∗∗P < 0.001 (Student's t test, n = 4). H–M. Quantification of Mapt/Tau (H), Mapt-S483 (I), Mapt-S500 (J), Mapt-S470 (K), Mapt-T473 (L), and Mapt-T523 (M) in five organs of K18-hACE2 mice. ∗P < 0.05, ∗∗P < 0.01, ∗∗∗P < 0.001 (Student's t test, n = 4). N. Quantification of hACE2 in five organs of K18-hACE2 mice. ∗P < 0.05, ∗∗P < 0.01, ∗∗∗P < 0.001 (Student's t test, n = 4).