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. Author manuscript; available in PMC: 2024 Jul 1.
Published in final edited form as: J Physiol. 2022 Sep 29;601(13):2685–2710. doi: 10.1113/JP283602

Figure 12 – Increasing CSQ-RyR regulation promotes SCRs, DADs and SAPs.

Figure 12 –

A) Increasing CSQ-RyR regulation monotonically decreases the rate threshold of SCRs (i), DADs (ii), and SAPs (iii) with the effect greater in cells with sparse and intermediate tubular structures vs cells with dense tubules. B) Effect of altered CSQ-RyR regulation on voltage (i) and global cytosolic Ca2+ concentration (ii) in cells with sparse (left), intermediate (middle), and dense (right) tubules following pacing at 3 Hz to examine the occurrence of DADs and SCRs.