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. Author manuscript; available in PMC: 2024 Jul 1.
Published in final edited form as: J Physiol. 2022 Sep 29;601(13):2685–2710. doi: 10.1113/JP283602

Figure 5 – Increasing surface/inner CRU NCX expression ratio inhibits simultaneous SCRs in inner coupled CRUs.

Figure 5 –

A) Rate threshold for local SCRs of surface (left), inner coupled (middle) and inner uncoupled (right) CRUs in sparse, intermediate and densely tubulated cells with the impact of altered surface/inner NCX expression ratio greatest in inner coupled CRUs of cells with dense and intermediate tubules. B) Cytosolic Ca2+ concentration of surface (left), inner coupled (middle) and inner uncoupled (right) CRUs from cells with dense (i), intermediate (ii), and sparse (iii) tubules following pacing at 3 Hz showing observed SCRs with varying surface/inner CRU NCX expression ratios.