Figure 7 – Inhibition of RyR has biphasic effects on SCRs in all CRUs.

A) Rate threshold for local SCRs of surface (left), inner coupled (middle) and inner uncoupled (right) CRUs in sparse, intermediate and densely tubulated cells with the impact of altered RyR expression ratio greatest in surface CRUs of all cells and inner coupled CRUs of cells with dense and intermediate tubules. B) Cytosolic Ca²⁺ concentration of surface (left), inner coupled (middle) and inner uncoupled (right) CRUs from cells with dense (i), intermediate (ii), and sparse (iii) tubules following pacing at 4 Hz showing observed SCRs with varying RyR fraction.