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. 2023 Feb 2;64(3):100339. doi: 10.1016/j.jlr.2023.100339

Fig. 2.

Fig. 2

Plasma-apoB concentrations, LDL-apoB fractional replacement rates (FRR) and apoB absolute synthesis rates (ASR) in noncirrhotic and cirrhotic NASH patients at baseline and after 12 weeks of ACCi. A: Plasma apoB concentrations in combined cirrhotic and noncirrhotic subjects were 106 ± 8 and 106 ± 9 mg/dl (mean ± SD, P = 0.9, N = 20) at baseline and week 12, respectively. B: Noncirrhotic plasma apoB concentrations were 115.5 ± 38.4 and 117.5 ± 34.7 mg/dl (mean ± SD, P = 0.6461, N = 10) at baseline and week 12, respectively. C: Cirrhotic plasma apoB concentrations were 96.3 ± 35.3 and 94.9 ± 41.1 mg/dl (mean ± SD, P = 0.6550, N = 10) at baseline and week 12, respectively. D: LDL-apoB FRR values ± SD in combined cirrhotic and noncirrhotic subjects were 31 ± 20.2 and 46 ± 22.6%/day (P = 0.03, N = 16) at baseline and week 12, respectively. E: Noncirrhotic LDL-apoB FRR values ± SD were 38.5 ± 22.6 and 40.5 ± 14.6%/day at baseline and week 12, respectively, (P = 0.8197, N = 8). F: Cirrhotic LDL-apoB FRR values ± SD were 23.5 ± 15.4 and 51.38 ± 28.6%/day (P = 0.006, N = 8) at baseline and week 12, respectively. G: Plasma-apoB ASR values in combined cirrhotic and noncirrhotic subjects were 30.4 ± 18.4 and 45.2 ± 15.4 mg/dl/day (P = 0.016, N = 16) at baseline and week 12, respectively. H: Noncirrhotic plasma-apoB ASR values ± SD were 39.8 ± 20.8 and 46.3 ± 14.8 mg/dl/day at baseline and week 12 (P = 0.5060, n=8), respectively. I: Cirrhotic plasma-apoB ASR values were 21.0 ± 9.6 and 44.2 ± 17 mg/dl/day at baseline and week 12 (P = 0.0021, N = 8), respectively. Plasma-apoB ASR was calculated as LDL-apoB100 FRR (fraction/day) x plasma-apoB concentration (mg/dl). Data are expressed as mean values ± SD. Statistical significance was calculated by a paired t test, ∗P ≤ 0.05. ACCi, acetyl-CoA carboxylase inhibitor; ASR, absolute synthesis rate; NASH, nonalcoholic steatohepatitis.