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. 2023 Mar 2;9:951704. doi: 10.3389/fcvm.2022.951704

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Copyright © 2023 Rui, Zhao, Yuhua and Hong.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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SMOC2 knockdown partially reversed the myocardial function loss. (A,B) SMOC2 expression after sh-RNA or sh-SMOC2 injection in mice heart (n = 6). (C) mRNA levels of SMOC2 after sh-RNA or sh-SMOC2 injection in mice heart (n = 6). (D) Representative images of echocardiographic measurement of cardiac function in mice. (E–L) Echocardiographic measurements of ejection fraction (EF), fractional shortening (FS), left ventricular internal diameter at end-systole (LVIDs), left ventricular internal diameter at end-diastole (LVIDd), HW/TL, HW/BW, interventricular septal thickness at diastole (IVS), and left ventricular posterior wall thickness at diastole (n = 8). *p < 0.05 vs. the control + sh-RNA group. ^#p < 0.05 vs. the ISO + sh-RNA group. n.s., non-significant.