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. 2023 Mar 2;14:1115226. doi: 10.3389/fphar.2023.1115226

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Copyright © 2023 Chen, Li and Du.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Schematic illustration of KLF family structures and domains (Adapted from Zhuoxiao Cao, Xinghui Sun, Basak Icli, et al. Role of Kruppel-like factors in leukocyte development, function, and disease. Blood, 2010, 116 (22):4404-14). (A) The structural characteristics of KLF family. (B) Differences in the AD/RD of partial KLF protein. AD, activation domain; RD, repression domain; NES, nuclear export signal; NLS, nuclear localization signal; N, N-terminus; C, C- terminus; PVALS/T, repression motif interacted with the corepressor CtBP2; SID, sin3 interaction domain; NA, not available.