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Schematic presentation of the molecular mechanism by which the KLF15 axis integrates metabolism. Fasting induces insulin secretion and then increases KLF15 expression, which is regulated by BTG and FOXO1/3A genes. Moreover, KLF15 is involved in the transformation of the three macronutrients (protein, carbohydrate, and fat) by targeting FGF21, PEPCK and SREBP-1 expression during fasting.
